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Structural Biology and Biophysics Seminar (SBBS)


D6: Structural Biology and Biophysics I – 73199 (Fall 2024)
D7: Structural Biology and Biophysics II – 73104 (Spring 2025)

(2 hrs/week; 1 CP) 

Stephan Grzesiek, Sebastian Hiller, Rod Lim, Timm Maier

The Structural Biology and Biophysics Seminar series (SBBS) is organized by PhD students of the Biozentrum, University of Basel since 2009. World-leading scientists are invited to present their current work to an audience of students, researchers and PIs. Typical lectures in this series describe applications of advanced structural biology and biophysics methods to solve biological problems. Methods include NMR spectroscopy, X-ray crystallography, cryo-electron microscopy, surface plasmon resonance and atomic force microscopy, but not only. The list of the past SBBS speakers is accessible here.

The talks take place on Tuesdays at 12:15, room U1.197

Unless mentioned, attendance is open to all interested people, without registration. The program for the spring semester 2025 is as follows:

February 18, 2025 at 12:15

 

SBBS introductory meeting for students 

If you missed the introduction meeting, feel free to contact one of the organisers by email or at the first seminar.

 

March 04, 2025 at 12:15, room U1.197

 

Probing the dynamics and interactions of disordered proteins with single-molecule spectroscopy: From disordered complexes to phase separation

The functions of proteins have traditionally been linked to their folded structures, but many proteins perform essential functions without being folded. Quantifying the highly dynamic and conformationally diverse ensembles of these intrinsically disordered proteins (IDPs) and their interaction mechanisms is an important aspect of understanding their functions. I will focus on highly charged IDPs and illustrate how single-molecule spectroscopy combined with simulations and other methods can be used to probe their dynamics, interactions, and phase separation.

 

 

Prof. Dr. Ben Schuler

Department of Biochemistry

University of Zurich

April 15, 2025 at 12:15, room U1.197

Exploring the molecular architecture of native actin assemblies using cryo-electron tomography

Actin contributes to an extraordinary range of cellular processes by assembling and disassembling highly dynamic and ordered structures. At the structural level, little is known about how the molecular players of the actin machinery work together inside cells to produce force-generating actin systems. In recent years, cryo-electron tomography (cryo-ET) has become the method of choice for structural analysis of the cell interior at the molecular level. In this talk, I will give a tour of our past and present cryo-ET work on different cellular actin structures and show how they have begun to open new avenues for understanding actin assembly in situ at the actin cytoskeleton-membrane interface.

 

 

Prof. Dr. Marion Jasnin

Helmholtz Pioneer Campus

Helmholtz Munich, Neuherberg

TBA, 2025 at 12:15, room U1.197

Title: TBA

TBA

TBA

May 06, 2025 at 12:15, room U1.197

Title: TBA

Prof. Dr. Ariane Briegel

Institut Pasteur, Paris

TBA, 2025 at 12:15, room U1.197

Title: TBA

TBA

TBA

May 20, 2025 at 12:15, room U1.197

Title: TBA

Prof. Dr. Robert Konrat

Department of Structural and Computational Biology

University of Vienna, Max Perutz Labs

Important information for students enrolled at the University of Basel:

  • You can earn one credit point (CP) by registering to the course.
  • To get the CP for this course, all of the proposed seminars have to be attended from start to finish and a written exam in the form of an essay must be passed.
  • It is your responsibility to check this website for eventual updates/changes to the program.
  • Each in-person seminar is followed by a lunch with the speaker. Contact the host if you are interested in participating.

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